Selective genetic inactivation of Caspase 8 in hepatocytes ameliorates progression of MASH following Jnk deficiency
Our findings define a protective role of JNK1/JNK2 in hepatocytes during the oxidative stress response driving the progression of MASH. This process is mainly mediated by Caspase 8-dependent apoptosis, thereby discovering that Caspase 8 is a downstream target of JNK1/2. Caspase 8-directed therapy in hepatocytes might be a promising treatment for patients with an increased oxidative stress response and MASH.
Authors
- Mark Kühnel (ORCID: https://orcid.org/0000-0003-3558-2576)
- Hilmar Berger (ORCID: https://orcid.org/0000-0002-6304-4946)
- Christian Trautwein (ORCID: https://orcid.org/0000-0003-2762-8247)
- Kai Markus Schneider (ORCID: https://orcid.org/0000-0002-0047-3794)
- Carolin Victoria Schneider (ORCID: https://orcid.org/0000-0002-6728-9246)
- Jan Georg Hengstler (ORCID: https://orcid.org/0000-0002-1427-5246)
- Lena Candels
- Cheng Lin (ORCID: https://orcid.org/0009-0007-2326-1536)
- Ines Volkert (ORCID: https://orcid.org/0009-0005-6094-8375)
- Stephanie Erschfeld
- Matthias Bartneck (ORCID: https://orcid.org/0000-0003-1516-9610)
- Ursula Schneider
- Julia Duda (ORCID: https://orcid.org/0000-0002-3894-0124)
- Adrien Guillot (ORCID: https://orcid.org/0000-0002-6002-9986)
- Karolina Edlund (ORCID: https://orcid.org/0000-0002-0276-2143)
- Danny Jonigk (ORCID: https://orcid.org/0000-0002-5251-2281)
- Julia Grube (ORCID: https://orcid.org/0000-0002-7225-4582)
- Jörg Rahnenführer (ORCID: https://orcid.org/0000-0002-8947-440X)
- Jana Dietrich (ORCID: https://orcid.org/0000-0001-7211-3168)
- Guo Nan Yin (ORCID: https://orcid.org/0000-0002-2512-7337)
- Frank Tacke (ORCID: https://orcid.org/0000-0001-6206-0226)
- Mohamed Ramadan Mohamed (ORCID: https://orcid.org/0000-0002-2101-2030)
- Roger J. Davis
- Marius Maximilian Woitok
Institutions
- University of Massachusetts Chan Medical School (US)
- TU Dortmund University (DE)
- DWI – Leibniz Institute for Interactive Materials (DE)
- German Center for Lung Research (DE)
- Klinikum Stuttgart (DE)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- Charité - Universitätsmedizin Berlin (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Hepatology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1097/hep.0000000000001286
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35