Repression of the ERRγ-CYP2E1 pathway by FGF4 mitigates alcohol-associated liver injury
Our study identifies FGF4 as a stress-responsive regulator in liver pathophysiology, operating through an FGFR4-mediated ERRγ-CYP2E1 signaling pathway. These results underscore the potential of FGF4 and its downstream pathways as therapeutic targets for ALD treatment.
Authors
- Shujun Zhi
- Yue Hu (ORCID: https://orcid.org/0000-0003-1792-4595)
- Siyu Liang (ORCID: https://orcid.org/0000-0002-3686-2679)
- Ming‐Hua Zheng (ORCID: https://orcid.org/0000-0003-4984-2631)
- Tongtong Pan (ORCID: https://orcid.org/0000-0003-4265-9623)
- Qiang Qiu (ORCID: https://orcid.org/0000-0001-5962-0309)
- Zhifeng Huang (ORCID: https://orcid.org/0000-0001-8269-6731)
- Wenliya Dong
- Xiaokun Li
- Lei Fan
- Luyao Wang (ORCID: https://orcid.org/0000-0003-1595-6593)
- Miaomiao Yang (ORCID: https://orcid.org/0000-0002-9933-3715)
- Hongru Kong (ORCID: https://orcid.org/0000-0002-2061-4611)
- Yushu Hou
- Lintao Song (ORCID: https://orcid.org/0000-0002-6476-7097)
- Zhuobing Huang
- Siyan Xu
- Jie Chen (ORCID: https://orcid.org/0009-0003-2727-0289)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1097/hep.0000000000001282
- Citations
- 5
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 4.03