Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC
Single-cell analysis has deepened our understanding of the molecular mechanism and tumor microenvironment in aggressive HCC. The combination of targeting tumor vasculature and blocking immune checkpoints represents a promising therapeutic strategy for this subtype.
Authors
- Keiichi Akahoshi (ORCID: https://orcid.org/0000-0003-3792-5659)
- Keita Kodera
- Daisuke Ban (ORCID: https://orcid.org/0000-0003-0868-8519)
- Megumi Hatano
- Shu Tsukihara (ORCID: https://orcid.org/0000-0003-2537-719X)
- Kohei Yagi
- Shinji Tanaka (ORCID: https://orcid.org/0000-0003-3906-6675)
- Tomohiko Taniai (ORCID: https://orcid.org/0000-0001-8911-5530)
- Koichiro Haruki (ORCID: https://orcid.org/0000-0002-1686-3228)
- Yoshiaki Tanji (ORCID: https://orcid.org/0009-0004-6585-3220)
- Toru Ikegami (ORCID: https://orcid.org/0000-0001-5792-5045)
- Koya Yasukawa (ORCID: https://orcid.org/0000-0002-3643-0921)
- Yasuhiro Asahina (ORCID: https://orcid.org/0000-0002-9900-0064)
- Yosuke Igarashi (ORCID: https://orcid.org/0000-0003-1998-8074)
- Shu Shimada (ORCID: https://orcid.org/0000-0002-4962-0636)
- Minoru Tanabe (ORCID: https://orcid.org/0000-0003-4875-1471)
- Atsushi Nara (ORCID: https://orcid.org/0000-0001-9233-8911)
- Kohei Okazaki
- Yoshimitsu Akiyama
Institutions
- Jikei University School of Medicine (JP)
- Tokyo Medical and Dental University (JP)
Publication Details
- Journal
- Hepatology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1097/hep.0000000000001284
- Citations
- 5
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 4.03