Inhibition of Hippocampal Neuronal Ferroptosis by Liproxstatin-1 Improves Learning and Memory Function in Aged Mice with Perioperative Neurocognitive Dysfunction
The results of this study suggest that isoflurane-induced ferroptosis may play an important role in the pathologic progression of PND. The application of liproxstatin-1, a lipid peroxidation inhibitor, provides a new potential therapeutic target for perioperative neuroprotection.
Authors
- Lanying Lin (ORCID: https://orcid.org/0000-0003-3862-1155)
- Limei Lin (ORCID: https://orcid.org/0000-0003-3375-3837)
- Jinghao Huang (ORCID: https://orcid.org/0000-0002-1938-5217)
- Linshen Huang
- Qian Zhou (ORCID: https://orcid.org/0000-0001-9304-6216)
- Ting Chen (ORCID: https://orcid.org/0000-0002-6838-3621)
- Xianzhong Lin
- Xin Ling
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s503784
- Citations
- 17
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 13.70