Design, Synthesis and Evaluation of Novel Cyclopropanesulfonamide Derivatives for the Treatment of EGFRC797S Mutation in Non-Small Cell Lung Cancer
We concluded that cyclopropylsulfonamide <b>5d</b> derivatives induce cell cycle arrest, apoptosis, and DNA damage by regulating tumor-related genes, thereby inhibiting the proliferation of C797S mutated lung cancer cells.
Authors
- Mengxuan Wang (ORCID: https://orcid.org/0000-0001-8935-6211)
- Wenyan Nie
- Haoran Nie
- Baijiao An (ORCID: https://orcid.org/0000-0001-7683-2389)
- Cuifang Yao
- Zhenhong Xia (ORCID: https://orcid.org/0000-0003-4537-659X)
- Shuai Zhang (ORCID: https://orcid.org/0000-0003-3243-5490)
- Yang Yang (ORCID: https://orcid.org/0000-0002-1163-2359)
- Ling Xu (ORCID: https://orcid.org/0000-0002-8144-8063)
- Chunlong Wang (ORCID: https://orcid.org/0000-0002-8511-1716)
- Jiaqi Qiu
Institutions
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/dddt.s490303
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 3.04