Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation
Our study demonstrates that Fangchinoline inhibits NPC growth by targeting SQLE and disrupting the PI3K/AKT pathway, providing new insights into SQLE as a therapeutic target in NPC.
Authors
- Jiuhuan Feng
- Jieyun Xie
- Lingling Sun (ORCID: https://orcid.org/0000-0001-7033-1698)
- Han Wang (ORCID: https://orcid.org/0000-0002-1253-5972)
- Zheng-Zheng Shi (ORCID: https://orcid.org/0000-0003-4397-6858)
- Yi-Hong Wu
- Huajie Lai
Institutions
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Songshan Lake Materials Laboratory (CN)
- Dongguan People’s Hospital (CN)
- Tang Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1016/j.phymed.2025.156484
- Citations
- 4
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.89