GREEN SYNTHESIS OF BENT SHAPED MESOGENIC THIADIAZOLES AND ITS PERFORMANCE EVALUATION OF BIOLOGICAL PROPERTIES AND CYTOTOXIC ACTIVITIES

While 80% of commercial medications are based on heterocyclic moieties,many synthesis processes lack sustainability, highlighting the need for environmentally friendly techniques. N-heterocyclic scaffolds play a crucial role in drug design, with an increasing number of new analogues demonstrating significant physiological and pharmacological value.To meet current demands for effective and sustainable methods,traditional synthetic protocols need modification. Recently,various techniques have been developed to promote the environmentally friendly production of important Nheterocyclic compounds. In this context, Rod shaped 4-substitutedbenzoic acid-N'-(4'-n-alkoxybenzoyl) hydrazide (series I) have been synthesized by the Schotten-Baumann reaction of 4-Subsitutedbenzhydrazide with 4-nalkoxybenzoyl chloride using triethyl amine as basic media in dry dichloromethane, as a solvent. The series I compounds have been cyclized to bent shaped mesogenic 2-(4'-Substituedphenyl)-5-(4”-n-alkoxyphenyl)-1, 3, 4- thiadiazoles (series II) using lawesson's reagent under microwave condition. The synthesized compounds are characterized by combination of elemental analysis and standard spectroscopic methods.In series II,all the synthesized compounds mesogenic properties.The biological properties and cytotoxic activities of mesogenic compounds in the present work are compared with each other to evaluate the effect on properties.