<scp>CCL17</scp>/<scp>CCR4</scp> Axis Promotes Hematoma Clearance via <scp>ERK</scp>/<scp>AP1</scp>/<scp>SRA</scp>‐Mediated Microglial Polarization After Intracerebral Hemorrhage
Our findings extend previous work by revealing that the CCL17/CCR4 axis enhances hematoma clearance through the ERK/AP1/SRA pathway-mediated microglial polarization. This mechanism represents a promising therapeutic target for ICH treatment.
Authors
- Shuixiang Deng (ORCID: https://orcid.org/0000-0001-5460-7279)
- Peng Jin (ORCID: https://orcid.org/0000-0001-5315-4343)
- Xianglan Chen (ORCID: https://orcid.org/0000-0002-9701-1595)
- Junjie Jin (ORCID: https://orcid.org/0000-0002-7964-4866)
- Yao Wang (ORCID: https://orcid.org/0000-0002-8801-8496)
Institutions
- University of Science and Technology of China (CN)
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/cns.70288
- Citations
- 1
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation