Impact of the polygenic risk scores for attention‐deficit/hyperactivity disorder in Alzheimer's disease
We calculated the genetic liability for attention-deficit/hyperactivity disorder (ADHD) using polygenic risk scores (ADHD-PRS). Elevated ADHD-PRS was associated with executive function deficits in individuals with mild cognitive impairment (MCI) or Alzheimer's disease (AD) dementia. Higher levels of cerebrospinal fluid (CSF) phosphorylated tau, but not amyloid beta (Aβ), were observed in dementia participants with higher ADHD-PRS. Higher ADHD-PRS was associated with brain hypometabolism in individuals with AD dementia. Hypometabolism in the parietal cortex mediated the effects of ADHD-PRS on executive function.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- João Pedro Ferrari‐Souza (ORCID: https://orcid.org/0000-0003-2183-1551)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Guilherme Povala (ORCID: https://orcid.org/0000-0002-2023-6569)
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Ann D. Cohen (ORCID: https://orcid.org/0000-0001-7395-9624)
- Carolina Soares (ORCID: https://orcid.org/0000-0002-2338-4495)
- Luís Augusto Rohde (ORCID: https://orcid.org/0000-0002-4552-4188)
- William E. Klunk (ORCID: https://orcid.org/0000-0001-5512-0251)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Victor L. Villemagne (ORCID: https://orcid.org/0000-0002-5832-9875)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Sarah Abbas
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Hussein Zalzale
- Maitê Schneider
- Brooke S. G. Molina (ORCID: https://orcid.org/0000-0001-7574-3755)
- Francieli Rohden (ORCID: https://orcid.org/0000-0002-9232-7371)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Oscar L. Lopez
- Eduardo R. Zimmer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- University of Pittsburgh (US)
- Hospital de Clínicas de Porto Alegre (BR)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.70003
- Citations
- 6
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Alzheimer's Association
- Global Brain Health Institute
- Alzheimer's Society
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- National Institutes of Health