Cas9 Mouse Model of Skull Base Meningioma Driven by Combinational Gene Inactivation in Meningeal Cells
The Cas9 mouse model of skull base meningioma generated with the Nf2 genetic defect and the combinational loss of P15<sup>Ink4b</sup>, P16<sup>Ink4a</sup>, and P19<sup>Arf</sup> could provide a new tool for investigating the pathogenesis of meningioma and the development of chemical interventions for this disease.
Authors
- Lingyang Hua (ORCID: https://orcid.org/0000-0002-1003-9289)
- Dan Sun (ORCID: https://orcid.org/0000-0003-2147-9308)
- Hailiang Tang (ORCID: https://orcid.org/0000-0003-1852-3128)
- Ji Xin Xiong
- Ping Zhong (ORCID: https://orcid.org/0000-0002-4415-2992)
- Ming Xu (ORCID: https://orcid.org/0000-0002-6998-8462)
- Jian Xu (ORCID: https://orcid.org/0000-0002-4251-6895)
- Feng Xu (ORCID: https://orcid.org/0000-0001-5185-2164)
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/cns.70287
- Citations
- 2
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 2.71