A head‐to‐head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic
Plasma p-tau biomarkers demonstrated higher diagnostic performance and larger effect sizes than t-tau and Aβ42/40 assays in detecting Alzheimer's disease. Among the p-tau biomarkers, p-tau217 assays consistently outperformed the others, providing superior classification of Aβ pathology status across different phosphorylation sites. p-tau217 assays showed the strongest correlation between plasma and CSF levels, indicating its potential as a reliable surrogate for CSF biomarkers. Several plasma p-tau biomarkers can be used in a specialized memory clinic to accurately detect Alzheimer's disease.
Authors
- Marta Milà‐Alomà (ORCID: https://orcid.org/0000-0002-5687-4597)
- Aida Fernández‐Lebrero (ORCID: https://orcid.org/0000-0002-2097-4430)
- José Contador (ORCID: https://orcid.org/0000-0002-9692-1570)
- Greta García‐Escobar
- Armand González‐Escalante (ORCID: https://orcid.org/0000-0001-9456-5405)
- Marta del Campo (ORCID: https://orcid.org/0000-0003-2808-3699)
- Esther Jiménez‐Moyano (ORCID: https://orcid.org/0000-0002-0005-6544)
- Qinyu Hao (ORCID: https://orcid.org/0000-0002-7059-7741)
- Aparna Sahajan
- Nathalie Le Bastard (ORCID: https://orcid.org/0000-0002-7981-2866)
- Paula Ortiz‐Romero (ORCID: https://orcid.org/0000-0002-6378-6763)
- Federica Anastasi (ORCID: https://orcid.org/0000-0002-9304-5421)
- Andreas Jeromin
- Bingqing Zhang (ORCID: https://orcid.org/0000-0003-0739-0956)
- Oriol Grau‐Rivera (ORCID: https://orcid.org/0000-0002-4730-5341)
- Gwendlyn Kollmorgen
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Margherita Carboni (ORCID: https://orcid.org/0000-0003-0426-8242)
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Albert Puig‐Pijoan (ORCID: https://orcid.org/0000-0002-9848-3711)
- Irene Navalpotro‐Gómez (ORCID: https://orcid.org/0000-0001-6863-5481)
- Nicholas J. Ashton
- Rosa María Manero-Borràs
- Kaj Blennow
- Alícia Nadal
- Tahmine Mousavi
- Javier Torres-Torronteras
Institutions
- Roche (Switzerland) (CH)
- Universidad San Pablo CEU (ES)
- Universitat Autònoma de Barcelona (ES)
- Alzheimer's Association (US)
- University of Wisconsin–Madison (US)
- Universitat Pompeu Fabra (ES)
- University of California, San Francisco (US)
- King's College London (GB)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- University of California System (US)
- Sorbonne Université (FR)
- Roche Pharma AG (Germany) (DE)
- Pasqual Maragall Foundation (ES)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Fujirebio (Japan) (JP)
- Centre for Genomic Regulation (ES)
- Banner Sun Health Research Institute (US)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Iberia (Spain) (ES)
- Institut du Cerveau (FR)
- Meso Scale Discovery (United States) (US)
- Banner Alzheimer’s Institute
- University College London (GB)
- Fujirebio (Belgium) (BE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14609
- Citations
- 21
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 24.45
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- “la Caixa” Foundation
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- Ministerio de Ciencia, Innovación y Universidades
- National Institute for Health and Care Research
- University College London
- European Commission
- Generalitat de Catalunya
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- Horizon 2020 Framework Programme
- HORIZON EUROPE Framework Programme
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- H2020 European Research Council