LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis

<i>Echinococcus multilocularis</i> is a tiny parasite with significant medical implications. The chronic parasitism of <i>E. multilocularis</i> in the liver generally leads to liver fibrosis, but the underlying mechanisms are poorly understood. We herein show that gm40262, a long noncoding RNA predominantly expressed in hepatic stellate cells (HSCs), is involved in hepatic fibrogenesis during infection by activating HSCs and promoting extracellular matrix production. The gm40262-orchestrating fibrogenesis occurs through the gm40262-miR-193b-5p-TLR4 and gm40262-miR-193b-5p-Col1α1 axes. The knockdown of gm40262 remarkably alleviates liver fibrosis, with decreased parasite growth. Our findings reveal a key role of gm40262 in liver fibrosis during <i>E. multilocularis</i> infection, rendering it a therapeutic target for hepatic fibrosis.

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Publication Details

Journal
mBio
Published
2025-04-09
DOI
https://doi.org/10.1128/mbio.02287-24
Citations
1
Primary Topic
Organ Transplantation Techniques and Outcomes
Type
article
Field-Weighted Citation Impact
2.01

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article

LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis

Ziyu Ye, Yadong Zheng, Xiaola Guo, Xuenong Luo et al.
1 citations
mBio
Organ Transplantation Techniques and Outcomes
2.01
article

LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis

Ziyu Ye, Yadong Zheng, Xiaola Guo, Xuenong Luo, Guiting Pu, Yong‐Yeon Cho, Hong Li, Yanping Li, Rui Li, Liqun Wang, Hong Yin
article en
1 citations

Abstract

<i>Echinococcus multilocularis</i> is a tiny parasite with significant medical implications. The chronic parasitism of <i>E. multilocularis</i> in the liver generally leads to liver fibrosis, but the underlying mechanisms are poorly understood. We herein show that gm40262, a long noncoding RNA predominantly expressed in hepatic stellate cells (HSCs), is involved in hepatic fibrogenesis during infection by activating HSCs and promoting extracellular matrix production. The gm40262-orchestrating fibrogenesis occurs through the gm40262-miR-193b-5p-TLR4 and gm40262-miR-193b-5p-Col1α1 axes. The knockdown of gm40262 remarkably alleviates liver fibrosis, with decreased parasite growth. Our findings reveal a key role of gm40262 in liver fibrosis during <i>E. multilocularis</i> infection, rendering it a therapeutic target for hepatic fibrosis.

mBioVol. 16(4)
Shanxi Medical University (CN), Lanzhou Veterinary Research Institute (CN), Queen Elizabeth Hospital (GB), Department of Animal Health (VN), Shanxi Fenyang Hospital (CN), Queen Elizabeth Hospital (CN), Zhejiang University of Technology (CN), Yangzhou University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 19%
Organ Transplantation Techniques and Outcomes
2.01
DOIOpen Access PDFOpenAlex
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