A Targeted Nanotoxin Inhibits Colorectal Cancer Growth Through Local Tumor Pyroptosis and Eosinophil Infiltration and Degranulation
These results highlight the dual role of CXCR4-targeted cytotoxic nanoparticle in eliminating cancer cells and boosting the self-immune response without compromising healthy organs.
Authors
- Eric Voltà‐Durán (ORCID: https://orcid.org/0000-0003-0017-8274)
- A.C. Virgili Manrique (ORCID: https://orcid.org/0000-0001-9733-6034)
- Luis Miguel Carrasco-Díaz (ORCID: https://orcid.org/0000-0003-0567-2802)
- Alberto Gallardo (ORCID: https://orcid.org/0000-0002-2514-2027)
- Patricia Álamo (ORCID: https://orcid.org/0000-0003-0510-5701)
- Ramón Mangues (ORCID: https://orcid.org/0000-0003-2661-9525)
- Ugutz Unzueta (ORCID: https://orcid.org/0000-0001-5119-2266)
- Esther Vázquez (ORCID: https://orcid.org/0000-0003-1052-0424)
- Antonio Villaverde (ORCID: https://orcid.org/0000-0002-2615-4521)
- David Páez (ORCID: https://orcid.org/0000-0002-5596-6588)
- Lorena Alba‐Castellón (ORCID: https://orcid.org/0000-0003-3449-7820)
- Isolda Casanova (ORCID: https://orcid.org/0000-0002-1196-4724)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Josep Carreras Leukaemia Research Institute (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/ijn.s499192
- Citations
- 6
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 12.04