A Nanostructure-Electrode-Based Electrochemical Sensor for Detection of Lactate Dehydrogenase

This paper reports on the development of nanostructure-electrode-based electrochemical sensors for detecting lactate dehydrogenase (LDH). Using an ultrathin nanopore template, gold nanostructured electrodes were fabricated. An on-chip specific chemical surface functionalization process was developed for the sensors for detecting LDH for the first time. Experiments showed the sensitivity has been improved, compared to the electrochemical sensors with plain electrodes. It has been found that at least ~5U/mL (~61 nM) of LDH can be readily detected.