CLINICAL PROFILE OF CHILDREN WITH EWING SARCOMA IN A TERTIARY CARE INSTITUTE-AN INSTITUTIONAL EXPERIENCE

Introduction: Ewing's Sarcoma Family of Tumors comprise a group of primary bone and soft-tissue tumors.The incidence of Ewing Sarcoma peaks in adolescence,slightly predominant in males.The common sites of occurrence are pelvis followed by extremities.The multimodal management of Ewing Sarcoma comprises of chemotherapy,surgery and radiotherapy.Our objective was to study the clinical profile of children with Ewing Sarcoma Methods: This is a retrospective analysis of children with Ewing Sarcoma admitted between January 2020 till November 2024.All the cases with IHC proven diagnosis of Ewing Sarcoma were reviewed.Relevant investigations including imaging and staging details were noted.Treatment was started as per EFT 2001 protocol.Clinical profile of the patient including age,gender,site of disease,stage of disease were noted.Treatment details of the patients were noted. Results: Total number of children with solid malignancies registered during this period were 322 and ES accounted for 54(16.7%)cases. 42(77.7%)children were males and 12(22.2%) were females.32 (59.2%) children belonged to the age group of 10-14 years.Around 44 (81.4%)children had osseous Ewing Sarcoma.At presentation,26(48.1%) children had metastases.All of them were started on Neo-adjuvant chemotherapy according to EFT 2001 protocol.26(48.1%) children had surgery as definitive therapy.Radiation was given in 40(74%)children.Limb salvage surgery was done in 18(69.2%) children.Amputation was done in 8(30.7%) children.Post local therapy,all of them received adjuvant chemotherapy.8(14.8%) children had relapse.The sites of relapse were lungs in 4(7.4%) children and local site plus lungs in 4(7.4%) children. Conclusions: In our institutional experience,majority were males.The primary site was osseous in majority of the children.Around 48.1% had metastases at the time of diagnosis.A multidisciplinary approach is needed in the management of Ewing Sarcoma.In our institution,all Ewing Sarcoma children received Neoadjuvant chemotherapy initially.Majority of our children received radiotherapy as definitive local therapy in view of unresectability