Plasma Microbial Cell-free DNA Sequencing for the Detection of Kingella kingae Pediatric Spinal Infections
Plasma mcfDNA sequencing offers a rapid, noninvasive method of detecting K. kingae causing pediatric spinal infections. This culture-independent approach may facilitate diagnosis, despite antibiotic pretreatment and subsequently targeted therapy and potentially obviate the need for biopsy.
Authors
- Audrey R. Lloyd (ORCID: https://orcid.org/0000-0001-5906-527X)
- Manuel R. Cotilla
- Asim A. Ahmed (ORCID: https://orcid.org/0000-0003-1340-8825)
- Catherine Foster (ORCID: https://orcid.org/0000-0002-2657-039X)
- Pablo Marcelo Laufer (ORCID: https://orcid.org/0000-0001-7214-8600)
- John Arnold
- Nazia Kabani
- Sarah Y. Park (ORCID: https://orcid.org/0000-0002-5997-2723)
- David W. Kimberlin (ORCID: https://orcid.org/0000-0001-9038-9109)
- Pablo Yagupsky (ORCID: https://orcid.org/0000-0003-4101-2609)
- Ana Del Valle Penella (ORCID: https://orcid.org/0009-0002-1767-6296)
- Carolina Sanchez‐Vegas
- Marian E. Melish
- Alejandro Jordán-Villegas
- Adriana Sarmiento Clemente (ORCID: https://orcid.org/0000-0002-3441-4995)
- Connie Trieu
- Matthew Smollin
- Martin Lindner (ORCID: https://orcid.org/0000-0002-9920-7305)
- L. E. R. Patterson
- Joshua Cooper
Institutions
- Ben-Gurion University of the Negev (IL)
- Boston Children's Hospital (US)
- Arkansas Children's Hospital (US)
- Baylor College of Medicine (US)
- Kapiolani Medical Center for Women and Children (US)
- Soroka Medical Center (IL)
- Arnold Palmer Hospital for Children (US)
- University of Alabama at Birmingham (US)
- University of Florida (US)
- Rady Children's Hospital-San Diego (US)
- East Tennessee Children's Hospital (US)
- Miami Children's Hospital (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1097/inf.0000000000004743
- Citations
- 5
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.03