Molecular evolution of nucleoside deoxyribosyl transferase to enhance the activity toward 2’-fluoro-2’-deoxynucleoside
The nucleoside deoxyribosyl transferase mutant were engineered to enhance biological activity and physical resistance for production of fluorinated deoxynucleoside as a raw material of oligonucleotide therapeutics.
Authors
- B K Kim
- Kang-Hyun Choi
- Yeon-Jin Yoo
- Sang-Jae Kang
- Eung Soo Kim (ORCID: https://orcid.org/0000-0001-6119-3158)
- S. Y. Yang (ORCID: https://orcid.org/0000-0002-1671-5866)
- Si-Sun Choi
Institutions
- Inha University (KR)
- Korea Pharma (South Korea) (KR)
Publication Details
- Journal
- Journal of Industrial Microbiology & Biotechnology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1093/jimb/kuaf005
- Citations
- 1
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 0.23