Amniotic fluid stem cell conditioned medium’s role in Schwann cell proliferation, survival, and cellular antioxidant activity under normative and oxidative stress conditions

AFS-CM enhances Schwann cell proliferation, viability, and resistance to oxidative stress, while reducing cellular senescence. These findings suggest that AFS-CM could be a promising adjunctive therapy for peripheral nerve injuries by promoting Schwann cell resilience and regenerative capacity. Future studies are needed to validate these <i>in vitro</i> results <i>in vivo</i> and explore their potential clinical application for improving functional recovery in patients with peripheral nerve damage.

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Publication Details

Journal
Annals of Translational Medicine
Published
2025-02-01
DOI
https://doi.org/10.21037/atm-24-107
Citations
1
Primary Topic
Nerve injury and regeneration
Type
article
Field-Weighted Citation Impact
0.91
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article

Amniotic fluid stem cell conditioned medium’s role in Schwann cell proliferation, survival, and cellular antioxidant activity under normative and oxidative stress conditions

Marcel G. Brown, Nequesha S. Mohamed, Xue Ma, Ayobami S. Ogunsola et al.
1 citations
Annals of Translational Medicine
Nerve injury and regeneration
0.91
article

Amniotic fluid stem cell conditioned medium’s role in Schwann cell proliferation, survival, and cellular antioxidant activity under normative and oxidative stress conditions

Marcel G. Brown, Nequesha S. Mohamed, Xue Ma, Ayobami S. Ogunsola, Chukwuweike U. Gwam, Kaitlin A. Henry
article en
1 citations

Abstract

AFS-CM enhances Schwann cell proliferation, viability, and resistance to oxidative stress, while reducing cellular senescence. These findings suggest that AFS-CM could be a promising adjunctive therapy for peripheral nerve injuries by promoting Schwann cell resilience and regenerative capacity. Future studies are needed to validate these <i>in vitro</i> results <i>in vivo</i> and explore their potential clinical application for improving functional recovery in patients with peripheral nerve damage.

Annals of Translational MedicineVol. 13(1)
Atrium Health Wake Forest Baptist (US)
Zero hunger
Openalex Percentile: Top 30%
Nerve injury and regeneration
0.91
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