Amniotic fluid stem cell conditioned medium’s role in Schwann cell proliferation, survival, and cellular antioxidant activity under normative and oxidative stress conditions
AFS-CM enhances Schwann cell proliferation, viability, and resistance to oxidative stress, while reducing cellular senescence. These findings suggest that AFS-CM could be a promising adjunctive therapy for peripheral nerve injuries by promoting Schwann cell resilience and regenerative capacity. Future studies are needed to validate these <i>in vitro</i> results <i>in vivo</i> and explore their potential clinical application for improving functional recovery in patients with peripheral nerve damage.
Authors
- Marcel G. Brown (ORCID: https://orcid.org/0000-0003-1553-5684)
- Nequesha S. Mohamed (ORCID: https://orcid.org/0000-0002-9597-0370)
- Xue Ma (ORCID: https://orcid.org/0000-0002-7650-6214)
- Ayobami S. Ogunsola (ORCID: https://orcid.org/0000-0002-5774-1163)
- Chukwuweike U. Gwam (ORCID: https://orcid.org/0000-0003-0579-3524)
- Kaitlin A. Henry
Institutions
- Atrium Health Wake Forest Baptist (US)
Publication Details
- Journal
- Annals of Translational Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/atm-24-107
- Citations
- 1
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.91