Study on the mechanism of Shuanghe decoction against steroid-induced osteonecrosis of the femoral head: insights from network pharmacology, metabolomics, and gut microbiota
SHD alleviates SONFH by reshaping gut microbiota, reversing metabolic imbalances, and enhancing osteogenesis. Our findings provide novel insights into the pharmacological mechanisms of SHD, laying a foundation for its clinical application in treating SONFH.
Authors
- Qiugen Wang
- Guoying Deng (ORCID: https://orcid.org/0000-0002-1693-8453)
- Wanxin Liu (ORCID: https://orcid.org/0009-0006-8958-1682)
- Xiaoqiang Wang (ORCID: https://orcid.org/0000-0002-1892-5613)
- Kai Zhu (ORCID: https://orcid.org/0000-0002-3721-8527)
- Yuanyuan Peng (ORCID: https://orcid.org/0000-0003-1864-9054)
- Zhenhao Wang (ORCID: https://orcid.org/0009-0005-0792-7452)
- Jun Zheng
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Yueyang Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s13018-025-05619-0
- Citations
- 1
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.72