Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatment
Our results highlight the necessity for personalized treatment strategies that consider genomic diversity beyond tumor markers, thus validating the utility of PDOs and PDOX models in advancing PDAC research and personalized medicine.
Authors
- Changhong Shi (ORCID: https://orcid.org/0000-0001-7490-3593)
- Yifan Ma (ORCID: https://orcid.org/0000-0002-9371-4365)
- Xiaowu Wang (ORCID: https://orcid.org/0000-0001-6753-227X)
- Gen Li (ORCID: https://orcid.org/0000-0003-3625-2210)
- Yong Zhao (ORCID: https://orcid.org/0000-0003-2850-3008)
- Mengyao Li (ORCID: https://orcid.org/0000-0002-3199-9465)
- Yongbin Zhang (ORCID: https://orcid.org/0000-0003-4198-5793)
- Peng Li (ORCID: https://orcid.org/0000-0003-3741-6387)
- Minli Huang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s13046-025-03332-8
- Citations
- 14
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 14.64
Funders
- National Natural Science Foundation of China