EIF4E-mediated biogenesis of circPHF14 promotes the growth and metastasis of pancreatic ductal adenocarcinoma via Wnt/β-catenin pathway
EIF4E-mediated biogenesis of circPHF14 stabilizes WNT7A mRNA via interaction with PABPC1, which subsequently activates the Wnt/β-catenin pathway, promoting the growth and metastasis of PDAC. These findings indicate that circPHF14 holds promise as a biomarker and therapeutic target for PDAC.
Authors
- Fang Zhou (ORCID: https://orcid.org/0000-0001-6912-2098)
- Chao Yu (ORCID: https://orcid.org/0000-0002-9244-9416)
- Zhuo Wu (ORCID: https://orcid.org/0000-0002-2654-5362)
- Liangtang Zeng
- Rufu Chen (ORCID: https://orcid.org/0000-0002-1883-1780)
- Qingyu Xie
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s12943-025-02262-5
- Citations
- 12
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 9.67
Funders
- National Natural Science Foundation of China
- Guangdong Provincial People's Hospital