Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination
Hv1 plays a role in diabetes-induced cognitive dysfunction by modulating neuroinflammation and myelin integrity. Hv1 KO demonstrates therapeutic potential in mitigating diabetes-related cognitive decline and associated complications.
Authors
- Zhixuan Zeng (ORCID: https://orcid.org/0000-0001-9740-1342)
- Jialu Xu (ORCID: https://orcid.org/0000-0002-1801-7682)
- Chunyu Li (ORCID: https://orcid.org/0000-0002-3930-332X)
- Shujun Zhang (ORCID: https://orcid.org/0000-0002-9103-7671)
- Yan Yang (ORCID: https://orcid.org/0000-0001-8146-8040)
- Delin Ma (ORCID: https://orcid.org/0000-0001-5039-7251)
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
- Hubei Provincial Women and Children's Hospital (CN)
- National Clinical Research (US)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- World Journal of Psychiatry
- Published
- 2025-02-26
- DOI
- https://doi.org/10.5498/wjp.v15.i3.101178
- Citations
- 1
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84