INDICATORS OF THE FUNCTIONS OF THE HEPATOBILIARY SYSTEM IN PATIENTS WITH CHRONIC OPISTHROCHISIS WITH GENETIC PREDISPOSITION TO THE DEVELOPMENT OF ARTERIAL HYPERTENSION

To assess the influence of genetic features associated with the development of arterial hypertension on the reactivity of the hepatobiliary system in opisthorchiasis invasion, a study of biochemical parameters was conducted in subgroups of patients with chronic opisthorchiasis with and without mutations in loci associated with a predisposition to this disease. It was found that the presence of a mutation in the rs1042713 locus of the ADRB2 gene increases deviations in ALP activity from the level of healthy individuals caused by opisthorchiasis invasion and slows down the normalization of ALT activity, but accelerates the decrease in cholesterol levels after treatment. Similar effects on ALP activity and ALT reaction after treatment are exerted by the AGT rs4762 polymorphism. The effect of another polymorphism of the same gene (AGT rs699) in CO seems to be rather positive: lower values of GGT activity and a decrease in ALT activity and cholesterol levels in response to therapy indicate less damage and faster normalization of hepatocyte functions. In the presence of the mutant allele of AGTR1 rs5186, liver dysfunctions in chronic opisthorchiasis are apparently aggravated (ALT activity and bilirubin levels are higher, alkaline phosphatase activity increases after treatment, although the bilirubin level decreases at this stage). The presence of a rare allele in the rs1799983 locus of the NOS3 gene in patients with opisthorchiasis prevents an increase in AM activity, but slows down the normalization of ALT and GGT activity after treatment. The effects of the studied polymorphisms on the process of changing biochemical parameters during therapy do not allow us to draw unambiguous conclusions, but may indicate a predominantly positive effect on the state of the hepatobiliary system in chronic opisthorchiasis of mutations in the AGT rs699 and NOS3 rs1799983 loci, and a predominantly negative effect in the ARDB2 rs1042713, AGT rs4762 and AGTR1 rs5186 loci.