Clinical and Pathologic Characteristics of Cytologically Indeterminate Thyroid Nodules with Non-V600E BRAF Alterations
ITNs harboring non-V600E <i>BRAF</i> alterations were rare (3.9% of patients) and typically malignant (73%). Nearly all nodules were benign or ATA low-risk cancers. Only 8% of such nodules were ATA intermediate or high risk cancers. In ITNs with isolated non-V600E <i>BRAF</i> and no other genetic alterations, one-third were non-malignant, and all cancers were ATA low risk. In the appropriate clinical context, thyroid lobectomy or active surveillance can be considered for initial management of non-V600E <i>BRAF</i>-altered ITNs.
Authors
- Ryan Instrum (ORCID: https://orcid.org/0000-0001-7618-2902)
- Babak Givi (ORCID: https://orcid.org/0000-0002-8221-5077)
- Bin Xu (ORCID: https://orcid.org/0000-0003-4638-9835)
- Christina E. Swartzwelder
- Brian R. Untch (ORCID: https://orcid.org/0000-0002-8379-5691)
- Richard J. Wong (ORCID: https://orcid.org/0000-0001-6259-7314)
- Luc G.T. Morris (ORCID: https://orcid.org/0000-0002-4417-2280)
- Ronald A. Ghossein
Institutions
- Memorial Sloan Kettering Cancer Center (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-02-22
- DOI
- https://doi.org/10.3390/cancers17050741
- Citations
- 2
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- National Computational Infrastructure