Nitric oxide delivery into oxygenators of artificial and assisted blood circulation. Current state and prospects of technology development (literature review)

The use of cardiopulmonary bypass (CPB) technologies is often associated with ischemic and re-perfusion injury to the myocardium. The contact of patient’s blood with the surface of the extracorporeal circuit leads to platelets activation and often triggers a systemic inflammatory reaction. Nitric oxide (NO) is a signal molecule produced by the endothelium of blood vessels. Under normal circumstances, it prevents excessive activation and aggregation of platelets, thus providing an organ-protective effect. Currently, there is a considerable amount of data available about positive effects of use of inhaled NO. Nitric oxide delivery into oxygenators of artificial and assisted blood circulation. However, there is a limited amount of publications on effects of NO delivery into gas circuit of oxygenators of artificial and assisted blood circulation. The objective of this article was to summarize currently available information about effects of NO delivery into extracorporeal circuits oxygenators through extensive literature review.