Intramedullary Spinal Cord Metastasis in Spinal Ependymomas
Drop metastasis, or intramedullary spinal cord metastasis (ISCM), is a rare condition accounting 0.9%-5% of CNS or spinal metastases. It arises from tumour cell dissemination through cerebrospinal fluid (CSF), often affecting the thoracic and lumbar spine. Clinical features include rapidly progressive neurological deficits, limb weakness, sensory loss, and pain. Diagnosing drop metastasis is challenging and MRI with gadolinium remains the gold standard modality for investigation. Surgical resection followed by radiotherapy remains the primary treatment option, whereas chemotherapy serves a palliative role in cases of recurrence or disseminated metastases.
Authors
- Zanib Javed (ORCID: https://orcid.org/0000-0002-7278-089X)
- Muhammad Shahzad Shamim (ORCID: https://orcid.org/0000-0001-8305-8854)
- Raheema Sadiq
- Hania Fatima
Institutions
- Aga Khan University Hospital (PK)
Publication Details
- Journal
- Journal of the Pakistan Medical Association
- Published
- 2025-02-23
- DOI
- https://doi.org/10.47391/jpma.25-22
- Primary Topic
- Management of metastatic bone disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00