Intramedullary Spinal Cord Metastasis in Spinal Ependymomas

Drop metastasis, or intramedullary spinal cord metastasis (ISCM), is a rare condition accounting 0.9%-5% of CNS or spinal metastases. It arises from tumour cell dissemination through cerebrospinal fluid (CSF), often affecting the thoracic and lumbar spine. Clinical features include rapidly progressive neurological deficits, limb weakness, sensory loss, and pain. Diagnosing drop metastasis is challenging and MRI with gadolinium remains the gold standard modality for investigation. Surgical resection followed by radiotherapy remains the primary treatment option, whereas chemotherapy serves a palliative role in cases of recurrence or disseminated metastases.

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Publication Details

Journal
Journal of the Pakistan Medical Association
Published
2025-02-23
DOI
https://doi.org/10.47391/jpma.25-22
Primary Topic
Management of metastatic bone disease
Type
article
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article

Intramedullary Spinal Cord Metastasis in Spinal Ependymomas

Zanib Javed, Muhammad Shahzad Shamim, Raheema Sadiq, Hania Fatima
Journal of the Pakistan Medical Association
Management of metastatic bone disease
article

Intramedullary Spinal Cord Metastasis in Spinal Ependymomas

Zanib Javed, Muhammad Shahzad Shamim, Raheema Sadiq, Hania Fatima
article en

Abstract

Drop metastasis, or intramedullary spinal cord metastasis (ISCM), is a rare condition accounting 0.9%-5% of CNS or spinal metastases. It arises from tumour cell dissemination through cerebrospinal fluid (CSF), often affecting the thoracic and lumbar spine. Clinical features include rapidly progressive neurological deficits, limb weakness, sensory loss, and pain. Diagnosing drop metastasis is challenging and MRI with gadolinium remains the gold standard modality for investigation. Surgical resection followed by radiotherapy remains the primary treatment option, whereas chemotherapy serves a palliative role in cases of recurrence or disseminated metastases.

Journal of the Pakistan Medical AssociationVol. 75(03)
Aga Khan University Hospital (PK)
Good health and well-being
Openalex Percentile: Top 94%
Management of metastatic bone disease
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