Arterial Collaterals and Endovascular Treatment Effect in Acute Ischemic Stroke with Large Infarct: A Secondary Analysis of the TENSION Trial

Background Randomized clinical trials have demonstrated that endovascular thrombectomy reduces functional disability in patients with large ischemic stroke; arterial collateral status might be used to select these patients for endovascular thrombectomy. Purpose To investigate whether arterial collateral status modifies the treatment effect of endovascular thrombectomy in patients with large ischemic stroke. Materials and Methods The Efficacy and Safety of Thrombectomy in Stroke with Extended Lesion and Extended Time Window (TENSION) trial was a prospective, multicenter, randomized study investigating participants with acute large ischemic stroke due to anterior circulation large-vessel occlusion. Participants with an Alberta Stroke Program Early CT Score of 3-5 were enrolled at 41 participating centers between July 2018 and February 2023. Participants were randomly assigned to undergo either endovascular thrombectomy with best medical treatment or best medical treatment alone within 12 hours from stroke onset. Collateral status was graded on pretreatment single-phase CT angiography (CTA) images using the Tan score and dichotomized into poor (grade, 0-1) or good (grade, 2-3) based on the extent of collateral supply filling the affected middle cerebral artery territory. The primary outcome was the shift on the 90-day modified Rankin Scale (mRS). Results Of 253 randomized patients, 201 with pretreatment CTA were included (median age, 74 years; IQR, 66-80 years; 103 [51.2%] female patients; 103 [51.2%] patients underwent endovascular thrombectomy). Endovascular thrombectomy compared with best medical treatment (adjusted common odds ratio [OR], 3.69; 95% CI: 2.12, 6.54; <i>P</i> < .001) and good collaterals compared with poor collaterals (adjusted common OR, 2.88; 95% CI: 1.63, 5.11; <i>P</i> < .001) were independently associated with a shift in the 90-day mRS scores toward better functional outcomes. The treatment effect of endovascular thrombectomy over best medical treatment was not modified by collateral status (interaction, <i>P</i> = .88). The treatment effect of endovascular thrombectomy versus best medical treatment was found in patients with good collaterals (adjusted common OR, 3.93; 95% CI: 1.65, 9.69; <i>P</i> = .002) and poor collaterals (adjusted common OR, 3.92; 95% CI: 1.86, 8.52; <i>P</i> < .001). Conclusion In this secondary analysis of data from the TENSION trial, endovascular thrombectomy reduced 90-day functional disability compared with best medical treatment in patients with good and poor collaterals. These findings suggest that patients with large ischemic stroke manifesting within 12 hours after onset should undergo endovascular thrombectomy irrespective of single-phase CTA collateral status. ClinicalTrials.gov Identifier: NCT03094715 © RSNA, 2025 <i>Supplemental material is available for this article.</i> See also the editorial by Benomar and Raymond in this issue.

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Journal
Radiology
Published
2025-02-01
DOI
https://doi.org/10.1148/radiol.242401
Citations
16
Primary Topic
Acute Ischemic Stroke Management
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article
Field-Weighted Citation Impact
21.67

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article

Arterial Collaterals and Endovascular Treatment Effect in Acute Ischemic Stroke with Large Infarct: A Secondary Analysis of the TENSION Trial

Alex Brehm, Franziska Dorn, Jan‐Erik Scholtz, Richard Novobilský et al.
16 citations
Radiology
Acute Ischemic Stroke Management
21.67
article

Arterial Collaterals and Endovascular Treatment Effect in Acute Ischemic Stroke with Large Infarct: A Secondary Analysis of the TENSION Trial

Alex Brehm, Franziska Dorn, Jan‐Erik Scholtz, Richard Novobilský, Stephen Ryan, Lars Udo Krause, Urs Fischer, Panagiotis Papanagiotou, Martin Čábal, Sarah Strickmann, Jan Raupach, María Alonso de Leciñana, Ferdinand Otto, Jana Zeleňáková, Waltraud Pfeilschifter, Taraneh Ebrahimi, Andreas Oldag, Andreas Kastrup, Grethe Andersen, Nader Sourour, Victoria Hellstern, Astrid Grams, Bernhard Glodny, Marie Louise Schmitz, Tomáš Křivka, Christian Förch, Juraj Cisár, Petar Trendafilov, Erendira Gabriela Boss, Elena de Celis, Vi Tuan Hua, Alena Šnajdrová, Brian Enriquez, Susanne Gellißen, Jan Purrucker, Götz Thomalla, Ján Haršány, Viktor Weiss, Jessica Jesser, Manuel Lunzer, Pedro Navía, Friedrich Weymayr, Constantin Hecker, Michal Panský, Daniela Thaler, Dominik F. Vollherbst, Sjur Prestsæter, Mostafa Ergawy, Emmanuel Chabert, Martin Bendszus, Sophie Crozier, Gabor C. Petzold, Markus Alfred Möhlenbruch, Michal Haršány, Tanja Janjic, Paolo Pagano, Rudolf Kreidenhuber, Elie Diamandis, Joachim Berkefeld, Anne Hege Aamodt, Christian Maegerlein, Erasmia Broussalis, Michael O. Breckwoldt, Helge C. Kniep, Alberto Álvarez, Jakub Soršák, Michael Kuschnerow, Pfaff Johannes, Ulrike Wießpeiner, Silke Hopf-Jensen, Daniel Spitzer, Bastian Cheng, Bjørn Tennøe, Maximilian Schell, Rocío Prieto‐Pérez, Olaf Adamczewski, L. Solymosi, Maximilian Leißner, Robert Forbig, Ulf Neuberger, Felix J. Bode, Ondřej Renc, Lars Tveit, Pavel Mencl, Joanna Oder, Monika Lauer, Jozef Haring, Inga Petersen, Florian Dazinger, Johannes Trenkler, Blanca Fuentes, Adam Krkoška, Eva Hassler, Annette Fromm, Antonı́n Krajina, Natalia Kurka, Maximilian Rauch, Sanja Karabegovic, Birte Mesche, Sebastian Fischer, Marián Ondrejkovič, Seraphine Zubel, Jan Borggrefe, Michael Städt, Leonardo Marques, Fabian Flottmann, Anushe Weber, Märit Jensen, G. Reimann, Rahman Al-Schameri, Krystian Figlewski, Kurt Niederkorn, Stephan Meckel, Ioannis Tsogkas, Christoph Kellinghaus, Ilona Eliášová, Nico Münnich, Egon Kurča, Martin Kovář, Lars Kellert, Rolf Ankerlund Blauenfeldt, Lukas Nussbaum, Dominik Michalski, Eva Hurtíková, Jean‐Christophe Ferré, Stefan Kiechl, Stefan Müller‐Hülsbeck, Ferdinand O. Bohmann, Christoph Polkowski, C. G. Schmidt, Aymeric Wittwer, Stanislava Jakubíček, Peter A. Ringleb, Asima Delalic, Florian Eff, Michal Bar, Quentin Alias, Kamila Volna, Susanne Bonekamp, Christian Herweh, Ronni Mikkelsen, Moritz Kronlage, Kévin Premat, Alexander Seiler, Marlies Wagner, Anna Ferrier, Kateřina Vališ, Susanne Lamprecht, Maya Hoelter, Gaute Kjellevold Wathle, Andrej Klepanec, Maria Barleben, Christian Brem, Sebastian Stösser, Milani Deb‐Chatterji, Werner Weber, Anne Léger, Agnieszka Delekta, Stella Breuer, Stefan Rohde, Alexander Pichler, P. 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Ryckborst, Peter Bernhard Sporns, Charlotte Rosso, Sarah Gelhard, Gerardo Ruiz, Martin Daniš, Mona Skjelland, Eckhard Schlemm, Boris Modrau, Tomáš Jonszta, Johannes Weller, Monika Killer‐Oberpfalzer, Jorge Rodríguez, Michael Kral, Volker Puetz, Eva Lenzenweger, Martin Vorčák, Slaven Pikija, Frank A. Wollenweber, Matthias Gawlitza, Stéphanie Lenck, Silke Wunderlich, Ricardo Rigual, Susanne Hörner, Mayank Goyal, Štefan Sivák, Wolfgang Wick, Harald Paukisch, Irena Doležalová, Nele Bubel, Karolina Skagen, Peter D. Schellinger, Nina Čurdová, Hans H. Henkes, Daniel Paech, Annemarie Brandhofe, Se-Jong You, Jesper Sømark, Jens Neumann, Katharina Wenger-Alakmeh, Silvia Schönenberger, Kamil Zeleňák, Marika Poulsen, Hannes Deutschmann, Johannes Gerber, Ursula Leitner, Jan Robert Kröger, Ondřej Strýček, Rüdiger Lange, Martina Petersen, Mirko Pham, Nikos Ntoulias, Daniel Schwarzenhofer, Tove Diedrichsen, Petra Brodová, Michele Damaskinos, Kristina DupontHougaard, Maiken Falkesgaard, Romana Galczak, Michail Panagiotis Giannakakis, Floriana Hacker-Ivan, Nina HjortJensen, Leif HougaardSoerensen, Hopp Katja, Natalia Keeba, Petra Keese, Christina Kefalaykos, Rita Lachmund, David Matyáš, Thormann Maximilian, Lukas Mayer-Süß, Oldřich Medek, Jan PlougmannPovlsen, Carlota Rivera-Bengoa, Thomas Röttcher, Milada Roztočilová, Jogrim Søyland, Karoline Volderauer, Poul VonWeitzel-Mudersbach, Lasse ZachoSpeiser, Fadha Elawi Al-Kuzae, Rolf AnkerlundBlaufeldt, Maria Bengtson Argren, Xénia Bavúzová, Rikke BayThomsen, Michael D. Hill, Andrés Fernández, Johannes Willeit, Jiří Vaníček, Victoria Hernández, Thomas Seifert‐Held, Julius N. Meißner, Martin Schaller, Ján Sýkora, Gernot Reimann, Sandra Becker, Stephen Delorme, Katharina Gruber, Julia Hoppe, Michael Preiß, Alexander Mohr, Claus Z. Simonsen, Angela Jedlitschka, Bohuslav Vojtíšek, Andrés Barrios, Marton Magyar, Elfi Boxhammer, Simon Fandler-Höfler, Joachim Gruber, Richard du Mesnil de Rochemont, Markus Holtmannspoetter, David Goldemund, E Bach, Sara Theisen, Sara Leder, Michael Görtler, Eva Vítková, Jan-Hendrik Schäfer, Eimad Shotar, Simen Sandvik, C Keil, Andrea Merkle, Tobias Breyer, Michael Augustin, Christoph Mönninghoff, Flore Baronnet, Stephan Lowens, Fatih Şeker, Georgi Krastev, Dorte Damgaard, Angélique Denis, Jasmin Retzlaff, Sylvia Beer, Casper Brekenfeld, Kollo Karen, Ramona Mücke, Sebastian Mutzenbach, Marios Psychogios, Maria Theresa Simonsen, Samp Patrick, Frau Heike, Anne Margrethe Kaalaas Størda
article en
16 citations

Abstract

Background Randomized clinical trials have demonstrated that endovascular thrombectomy reduces functional disability in patients with large ischemic stroke; arterial collateral status might be used to select these patients for endovascular thrombectomy. Purpose To investigate whether arterial collateral status modifies the treatment effect of endovascular thrombectomy in patients with large ischemic stroke. Materials and Methods The Efficacy and Safety of Thrombectomy in Stroke with Extended Lesion and Extended Time Window (TENSION) trial was a prospective, multicenter, randomized study investigating participants with acute large ischemic stroke due to anterior circulation large-vessel occlusion. Participants with an Alberta Stroke Program Early CT Score of 3-5 were enrolled at 41 participating centers between July 2018 and February 2023. Participants were randomly assigned to undergo either endovascular thrombectomy with best medical treatment or best medical treatment alone within 12 hours from stroke onset. Collateral status was graded on pretreatment single-phase CT angiography (CTA) images using the Tan score and dichotomized into poor (grade, 0-1) or good (grade, 2-3) based on the extent of collateral supply filling the affected middle cerebral artery territory. The primary outcome was the shift on the 90-day modified Rankin Scale (mRS). Results Of 253 randomized patients, 201 with pretreatment CTA were included (median age, 74 years; IQR, 66-80 years; 103 [51.2%] female patients; 103 [51.2%] patients underwent endovascular thrombectomy). Endovascular thrombectomy compared with best medical treatment (adjusted common odds ratio [OR], 3.69; 95% CI: 2.12, 6.54; <i>P</i> < .001) and good collaterals compared with poor collaterals (adjusted common OR, 2.88; 95% CI: 1.63, 5.11; <i>P</i> < .001) were independently associated with a shift in the 90-day mRS scores toward better functional outcomes. The treatment effect of endovascular thrombectomy over best medical treatment was not modified by collateral status (interaction, <i>P</i> = .88). The treatment effect of endovascular thrombectomy versus best medical treatment was found in patients with good collaterals (adjusted common OR, 3.93; 95% CI: 1.65, 9.69; <i>P</i> = .002) and poor collaterals (adjusted common OR, 3.92; 95% CI: 1.86, 8.52; <i>P</i> < .001). Conclusion In this secondary analysis of data from the TENSION trial, endovascular thrombectomy reduced 90-day functional disability compared with best medical treatment in patients with good and poor collaterals. These findings suggest that patients with large ischemic stroke manifesting within 12 hours after onset should undergo endovascular thrombectomy irrespective of single-phase CTA collateral status. ClinicalTrials.gov Identifier: NCT03094715 © RSNA, 2025 <i>Supplemental material is available for this article.</i> See also the editorial by Benomar and Raymond in this issue.

RadiologyVol. 314(2)
Université Claude Bernard Lyon 1 (FR), Goethe University Frankfurt (DE), Oslo University Hospital (NO), Innsbruck Medical University (AT), University of Trnava (SK), Witten/Herdecke University (DE), Universität Hamburg (DE), University of Calgary (CA), National and Kapodistrian University of Athens (GR), Medical University of Graz (AT), Norwegian University of Science and Technology (NO), Charles University (CZ), Masaryk University (CZ), Heidelberg University (DE), University Hospital Bonn (DE), Hospital Universitario La Paz (ES), German Center for Neurodegenerative Diseases (DE), University Hospital Heidelberg (DE), Aarhus University Hospital (DK), Foothills Medical Centre (CA), DIAKO (DE), Hospices Civils de Lyon (FR), University Hospital Brno (CZ), Hospital La Paz Institute for Health Research (ES), Centre Hospitalier Universitaire de Reims (FR), University Medical Center Hamburg-Eppendorf (DE), Universitätsklinikum Würzburg (DE), University Hospital Frankfurt (DE), Laboratoire de Biométrie et Biologie Evolutive (FR), St. Anne's University Hospital Brno (CZ), Klinikum Bremen-Mitte (DE), Klinik und Poliklinik für Psychotherapie und Psychosomatik (DE), Hôpital Maison Blanche (FR), Universidad Autónoma de Madrid (ES), Comenius University Bratislava (SK), Université de Reims Champagne-Ardenne (FR)
Horizon 2020
Good health and well-being
Openalex Percentile: Top 0%
Acute Ischemic Stroke Management
21.67
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