Advancing Heart Valve Replacement: Risk Mitigation of Decellularized Pulmonary Valve Preparation for Its Implementation in Public Tissue Banks
The studies performed and reviewed bibliography were able to significantly reduce the original level of risk associated with the clinical application of this homograft's preparation. However, additional in vivo studies and tissue stability tests are still necessary to address the remaining risks associated with reagents' effect on extracellular matrix and storage conditions, which could influence implant failure, before the clinical evaluation procedures can be implemented to determine the efficacy and safety of the new decellularized heart valves.
Authors
- Maria Luisa Pérez (ORCID: https://orcid.org/0000-0003-4558-5498)
- Anna Vilarrodona (ORCID: https://orcid.org/0000-0001-6984-1834)
- María Eugenia Fernández‐Santos (ORCID: https://orcid.org/0000-0001-9229-0022)
- Antonio Ocampo (ORCID: https://orcid.org/0000-0002-3176-9758)
- Diletta Trojan (ORCID: https://orcid.org/0000-0002-9003-9421)
- Giulia Montagner (ORCID: https://orcid.org/0000-0003-4978-8209)
- Ramadan Jashari (ORCID: https://orcid.org/0000-0002-0867-1998)
- Elba Agustí
- Jose Ignacio Rodríguez Martínez (ORCID: https://orcid.org/0000-0002-3379-9686)
- Ana Rita Piteira (ORCID: https://orcid.org/0000-0002-6161-7931)
- Jaime Tabera (ORCID: https://orcid.org/0000-0002-5430-0151)
- Pablo Martínez‐Legazpi (ORCID: https://orcid.org/0000-0003-0511-7120)
- Cristina Castells‐Sala (ORCID: https://orcid.org/0000-0002-7520-5401)
- Javier Bermejo
Institutions
- Universidad Complutense de Madrid (ES)
- Cliniques Universitaires Saint-Luc (BE)
- Universidad Nacional de Educación a Distancia (ES)
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Veneto Eye Bank Foundation (IT)
- Biomedical Research Institute (US)
- Banc de Sang i Teixits (ES)
Publication Details
- Journal
- Therapeutics and Clinical Risk Management
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/tcrm.s486508
- Citations
- 2
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78