Quercetin, a Compound of the Total Flavonoids of Periploca forrestii Schltr., Ameliorates Rheumatoid Arthritis by Targeting TNF-α
Quercetin, a compound of TFPF, interacts with and inhibits the activity of TNF-α, thereby suppressing the TNF-α/NF-κB signaling pathway and alleviating the symptoms of RA. These findings position quercetin as a promising TNF-α inhibitor for the treatment of RA.
Authors
- Zhongxiu Wu
- Lin Zheng (ORCID: https://orcid.org/0000-0001-6495-7416)
- Wei-Na Xue
- Ding-Yan Lu (ORCID: https://orcid.org/0000-0003-3098-2642)
- Shuaishuai Chen (ORCID: https://orcid.org/0000-0002-5491-6650)
- Yongjun Li (ORCID: https://orcid.org/0000-0002-0479-6259)
- Yong‐Lin Wang (ORCID: https://orcid.org/0000-0002-7109-2825)
- Meng Zhou (ORCID: https://orcid.org/0000-0003-0337-9602)
- Ting Liu (ORCID: https://orcid.org/0000-0002-5824-3975)
Institutions
- National United University (TW)
- Guiyang Medical University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Zhejiang Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s497166
- Citations
- 8
- Primary Topic
- Phytochemistry and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 4.78