Moderation of midlife cognitive activity on tau‐related cognitive impairment
Greater midlife cognitive activity (CA) was generally associated with better cognitive performance in a given amount of tau pathology. Paradoxically, higher levels of midlife CA were related to a more rapid tau-related cognitive decline in already cognitively impaired individuals. Late-life CA did not exhibit any moderation effect on the association between tau and cognitive performance or decline.
Authors
- Yoon Young Chang (ORCID: https://orcid.org/0009-0006-0279-1880)
- Yu Kyeong Kim (ORCID: https://orcid.org/0000-0002-3282-822X)
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- Nayeong Kong (ORCID: https://orcid.org/0000-0002-9095-1701)
- Musung Keum (ORCID: https://orcid.org/0000-0002-0855-8637)
- Yun‐Sang Lee (ORCID: https://orcid.org/0000-0003-1640-2090)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-6613-4680)
- Kang Ko (ORCID: https://orcid.org/0000-0001-9457-3456)
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Dong Young Lee (ORCID: https://orcid.org/0000-0001-8976-8320)
- Joon Hyung Jung
Institutions
- Seoul National University (KR)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Inje University Sanggye Paik Hospital (KR)
- National Health Insurance Service Ilsan Hospital (KR)
- Chungbuk National University Hospital (KR)
- Keimyung University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14606
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Korea Health Industry Development Institute
- National Institute on Aging