GLP‐1RA‐induced delays in gastrointestinal motility: Predicted effects on coadministered drug absorption by PBPK analysis
PBPK modeling suggests that GLP-1RAs can influence the pharmacokinetics of oral medications by delaying gastric emptying, potentially leading to clinically relevant DDIs. While further clinical validation and pharmacovigilance is needed, these findings highlight the importance of PBPK tools in predicting and potentially mitigating risks associated with GLP-1RA use.
Authors
- Shuhan Liu (ORCID: https://orcid.org/0000-0002-6627-4843)
- Manjunath P. Pai (ORCID: https://orcid.org/0000-0001-7119-5034)
- Levi Hooper (ORCID: https://orcid.org/0000-0002-0537-8702)
Institutions
- University of Michigan (US)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1002/phar.70007
- Citations
- 10
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 12.95
Funders
- National Center for Advancing Translational Sciences