Plasma Alzheimer's disease biomarker relationships with incident abnormal amyloid PET
Plasma phosphorylated tau 217 was associated with amyloid positron emission tomography progression, negative to positive. The associations were weaker for amyloid beta 42/40 and Amyloid Probability Score 2. Age and apolipoprotein E ε4 carriership were also important predictors. These markers may be useful for enrichment of a primary prevention trial.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Philip B. Verghese (ORCID: https://orcid.org/0000-0003-4793-564X)
- Petrice M. Cogswell (ORCID: https://orcid.org/0000-0002-8128-4476)
- Jeffrey L. Gunter (ORCID: https://orcid.org/0000-0001-7813-9078)
- Terry M. Therneau (ORCID: https://orcid.org/0000-0003-1490-6711)
- Jonathan Graff‐Radford
- Stephen D. Weigand (ORCID: https://orcid.org/0000-0002-4541-9011)
- Tim West (ORCID: https://orcid.org/0000-0003-3267-8249)
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Joel B. Braunstein (ORCID: https://orcid.org/0000-0002-1155-0206)
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Michael Griswold (ORCID: https://orcid.org/0000-0001-8106-5516)
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
Institutions
- Mayo Clinic (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- C2N Diagnostics (United States) (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14629
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Institutes of Health