Influence of cognitive impairment and race on plasma p‐Tau <sub>217</sub> in two diverse cohorts
Cognitive impairment associates with plasma p-Tau<sub>217</sub> independent of CSF biomarkers. Black/African Americans had lower plasma p-Tau<sub>217</sub> than non-Hispanic White Americans. CSF p-Tau<sub>181</sub> could not explain lower plasma p-Tau<sub>217</sub> in Black/African Americans. Plasma p-Tau<sub>217</sub> difference results in more false positive cases according to race. Novel CSF processes were associated with race-related plasma p-Tau<sub>217</sub> difference.
Authors
- Victor Sotelo (ORCID: https://orcid.org/0009-0003-1251-6928)
- William T. Hu (ORCID: https://orcid.org/0000-0003-4862-6777)
- Milota Kaluzová
- Ashima Nayyar
- Mei‐Ling Li
- Karthik Kota (ORCID: https://orcid.org/0000-0001-5012-7382)
- Malgorzata Migut
- Mini Jomartin
- Isabelle Hwang
- Hilary Grosso Jasutkar (ORCID: https://orcid.org/0000-0002-1441-2191)
- Guibin Su
- Karlyndsay Sitterley
Institutions
- Rutgers, The State University of New Jersey (US)
- Johnson University (US)
- Institute on Aging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14585
- Citations
- 11
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 16.18
Funders
- Fujirebio US
- National Institutes of Health
- National Institute on Aging