Cognitive vulnerability to glucose fluctuations: A digital phenotype of neurodegeneration
Cognitive vulnerability to glucose (CVG) may be a useful digital phenotype of neurodegeneration. We used cognitive ecological momentary assessment and continuous glucose monitoring to investigate CVG's associations with plasma biomarkers. Associations of CVG for sustained attention and phosphorylated tau 181 remained significant across covariates. We discuss possible mechanisms relating glucose variability, cognition, and neurodegeneration.
Authors
- Michal Schnaider Beeri (ORCID: https://orcid.org/0000-0002-4254-9742)
- Kamille Janess (ORCID: https://orcid.org/0000-0001-5771-4133)
- Laura Thi Germine (ORCID: https://orcid.org/0000-0001-8690-8412)
- Laneé Jung (ORCID: https://orcid.org/0000-0003-3555-5287)
- Zoë Hawks (ORCID: https://orcid.org/0000-0002-3796-0289)
- Shafaq Rizvi
- Naomi Chaytor (ORCID: https://orcid.org/0000-0001-8821-289X)
- Richard E. Pratley (ORCID: https://orcid.org/0000-0002-2912-1389)
- Yogish C. Kudva (ORCID: https://orcid.org/0000-0003-0285-6622)
- Jane Bulger (ORCID: https://orcid.org/0000-0002-3585-4896)
- Martin J. Sliwinski (ORCID: https://orcid.org/0000-0002-9611-7558)
- Ruth S. Weinstock (ORCID: https://orcid.org/0000-0001-5859-5666)
- Michael Roehrhoff Rickels (ORCID: https://orcid.org/0000-0002-9253-838X)
- Pia Kivisäkk (ORCID: https://orcid.org/0000-0001-9708-7509)
- Luciana Mascarenhas Fonseca (ORCID: https://orcid.org/0000-0002-2849-0545)
- Elizabeth Grinspoon (ORCID: https://orcid.org/0000-0002-5608-8254)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
Institutions
- Rutgers, The State University of New Jersey (US)
- Brigham and Women's Hospital (US)
- Pennsylvania State University (US)
- Mayo Clinic (US)
- Harvard University (US)
- Washington State University Spokane (US)
- Universidade de São Paulo (BR)
- SUNY Upstate Medical University (US)
- AdventHealth Orlando (US)
- McLean Hospital (US)
- WinnMed (US)
- Massachusetts General Hospital (US)
- Translational Research Institute for Metabolism and Diabetes (US)
- Jaeb Center for Health Research (US)
- University of Pennsylvania (US)
- Georgia Highlands College (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.70001
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- Alzheimer's Association
- University of Washington
- National Institutes of Health
- National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases