The role of insulin resistance and <i>APOE</i> genotype on blood–brain barrier integrity in Alzheimer's disease
Insulin resistance and apolipoprotein E (APOE) genotype are well-recognized risk factors for Alzheimer's disease (AD). Insulin resistance shows high prevalence in patients with AD. Insulin resistance is related to damage in blood-brain barrier (BBB) integrity. The association between the triglyceride-glucose (TyG) index and BBB permeability varies in relation to APOE genotype; patients with the APOE ε4/ε4 displayed higher BBB permeability.
Authors
- Tiago F. Outeiro (ORCID: https://orcid.org/0000-0003-1679-1727)
- Andrea Pilotto (ORCID: https://orcid.org/0000-0003-2029-6606)
- Chiara Tolassi (ORCID: https://orcid.org/0009-0006-8741-1313)
- Elena Bazzoli
- Alberto Benussi (ORCID: https://orcid.org/0000-0002-8703-6940)
- Salvatore Caratozzolo (ORCID: https://orcid.org/0000-0001-5579-9081)
- Ilenia Libri (ORCID: https://orcid.org/0000-0001-7334-5075)
- Alice Galli (ORCID: https://orcid.org/0009-0009-7804-5106)
- Alessandro Padovani (ORCID: https://orcid.org/0000-0002-0119-3639)
- Bianca Gumina
Institutions
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Biosensor (Italy) (IT)
- University of Brescia (IT)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14556
- Citations
- 17
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 19.79
Funders
- Fondazione Cariplo
- Ministero della Salute
- Associazione Italiana Ricerca Alzheimer
- Horizon 2020 Framework Programme