Evaluation of two plasma‐based proteotyping assays against <i>APOE</i> ε4 genotyping in a memory clinic setting: The Gothenburg H70 Clinical Studies
Plasma-based proteotyping presented good to excellent sensitivity in identifying apolipoprotein E (APOE) ε4 homozygosity. The negative predictive value was also very good to excellent, allowing us to rule out APOE ε4 homozygosity with high precision. Assays with excellent precision show potential for identifying individuals for definitive APOE ε4 genotyping in a two-step approach.
Authors
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Andréa Lessa Benedet (ORCID: https://orcid.org/0000-0001-8219-1741)
- Kina Höglund (ORCID: https://orcid.org/0000-0002-1213-9953)
- Ingmar Gr. Skoog (ORCID: https://orcid.org/0000-0002-9803-3438)
- Anna Dittrich (ORCID: https://orcid.org/0000-0002-5168-2975)
- Silke Kern (ORCID: https://orcid.org/0000-0001-7617-7214)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Kübra Tan (ORCID: https://orcid.org/0000-0002-9092-2118)
Institutions
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- University of Arizona (US)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Region Västra Götaland (SE)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Banner Sun Health Research Institute (US)
- Institut du Cerveau (FR)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14610
- Citations
- 7
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.15
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- European Partnership on Metrology
- National Institute for Health and Care Research
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- Norges Forskningsråd
- Sahlgrenska Universitetssjukhuset
- Göteborgs Universitet
- Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Kirsten og Freddy Johansens Fond
- Stiftelsen Psykiatriska Forskningsfonden
- Alzheimerfonden
- University College London Hospitals NHS Foundation Trust
- UK Dementia Research Institute
- Olav Thon Stiftelsen
- Fondation pour la Recherche sur Alzheimer
- Horizon 2020 Framework Programme
- HORIZON EUROPE Framework Programme
- UCLH Biomedical Research Centre
- H2020 Marie Skłodowska-Curie Actions