Longitudinal patterns of brain aging and neurodegeneration among older adults with dual decline in memory and gait
Those experiencing dual decline showed several accelerated brain atrophy patterns. Those experiencing dual decline showed unique microstructural deterioration. Dual decline showed a greater decline in plasma Aβ<sub>42/40</sub> ratio. Dual decline showed greater increases in plasma GFAP and NfL. Dual decline may indicate brain and blood markers underlying dementia.
Authors
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Michael R. Duggan (ORCID: https://orcid.org/0000-0002-1029-4423)
- Qu Tian (ORCID: https://orcid.org/0000-0003-2706-1439)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Erin E. Greig
- Zhijian Yang (ORCID: https://orcid.org/0000-0002-5143-0890)
- Bennett A. Landman
- Luigi Ferrucci
Institutions
- Intel (United States) (US)
- Johns Hopkins University (US)
- Vanderbilt University (US)
- Johns Hopkins Medicine (US)
- National Institute on Aging (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14612
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- National Institute on Aging