BTK‐Inhibition Enhances TLR‐7‐Mediated Interferon‐Alpha Production in pDCs by Blocking the Inhibitory BDCA‐2 Pathway
In pDCs, BTK-inhibition (BTKi) blocks the IFN-α production via TLR-9, but not via TLR-7. Upon TLR-7 stimulation, BTKi enhances the production of IFN-α by blocking the inhibitory BDCA-2 pathway. This might explain partially the failure of BTKi in SLE and is of interest for BTKi trials in multiple sclerosis.
Authors
- Christian Wichmann (ORCID: https://orcid.org/0000-0001-5341-8804)
- Edgar Meinl (ORCID: https://orcid.org/0000-0002-2570-6785)
- Anneli Peters (ORCID: https://orcid.org/0000-0002-8259-2219)
- Vinícius Boldrini (ORCID: https://orcid.org/0000-0003-3984-2689)
- Ramona Gerhards (ORCID: https://orcid.org/0000-0002-5398-3632)
- Laura Ceglarek (ORCID: https://orcid.org/0009-0005-7117-0335)
Institutions
- University of Zurich (CH)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Immunology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/eji.202450985
- Citations
- 1
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Alexander von Humboldt-Stiftung
- Deutsche Forschungsgemeinschaft
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Ludwig-Maximilians-Universität München