Gene Expression Changes Precede Elevated Mechanical Sensitivity in the Mouse Intervertebral Disc Injury Model
The RNASeq data revealed numerous early genes that participate in inflammation and repair processes post IVD injury. Mechanical allodynia followed these gene expression changes.
Authors
- Ken Chen (ORCID: https://orcid.org/0009-0004-8327-1179)
- Frances S. Shofer (ORCID: https://orcid.org/0000-0001-6813-4791)
- Zuozhen Tian
- Ling Qin (ORCID: https://orcid.org/0000-0002-2582-0078)
- Brianna Ciesielski
- William T. O’Brien (ORCID: https://orcid.org/0000-0002-9966-0134)
- Yejia Zhang (ORCID: https://orcid.org/0000-0002-7484-8800)
- Huan Wang (ORCID: https://orcid.org/0000-0003-1115-143X)
Institutions
- Central South University (CN)
- Philadelphia VA Medical Center (US)
- Xiangya Hospital Central South University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- University of Pennsylvania (US)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1002/jsp2.70049
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Children's Hospital of Philadelphia
- University of Pennsylvania
- Institute for Translational Medicine and Therapeutics
- National Institutes of Health
- Intellectual and Developmental Disabilities Research Center
- VISN 4 Mental Illness Research, Education, and Clinical Center
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Penn Center for Musculoskeletal Disorders