Retinal vascular alterations in cognitive impairment: A multicenter study in China
A deep learning segmentation model extracted diverse retinal vascular features. Significant alterations in the structure of retinal arterial/venous networks were identified. Partitioning vessel-rich retinal zones improved detection of vascular changes. Decreases in vessel length, segment number, and vascular density were found in CI individuals.
Authors
- Hao Zheng (ORCID: https://orcid.org/0000-0001-5769-6035)
- Andrew Ni
- Qianhua Zhao (ORCID: https://orcid.org/0000-0001-5655-158X)
- Biao Yan (ORCID: https://orcid.org/0000-0002-7338-6413)
- Zhenxu Xiao (ORCID: https://orcid.org/0000-0002-6598-0367)
- Wanqing Wu (ORCID: https://orcid.org/0000-0003-0932-8785)
- Wenxin Su (ORCID: https://orcid.org/0000-0002-5470-5853)
- Kaiwen Shi (ORCID: https://orcid.org/0000-0001-5440-6442)
- Timothy Kwok (ORCID: https://orcid.org/0000-0001-9253-3549)
- Kexin Li (ORCID: https://orcid.org/0000-0003-3006-3582)
- Ding Ding (ORCID: https://orcid.org/0000-0001-8747-6009)
- Jiayi Zhang (ORCID: https://orcid.org/0000-0002-1575-0723)
- Wenbin Xie
- Mingxuan Wang (ORCID: https://orcid.org/0000-0002-1107-4035)
- Peijun Zhang (ORCID: https://orcid.org/0000-0002-2321-5384)
- Qin Shi (ORCID: https://orcid.org/0000-0002-8694-2685)
Institutions
- University of Essex (GB)
- Johns Hopkins University (US)
- Chinese University of Hong Kong (HK)
- Fudan University (CN)
- Brown University (US)
- Eye & ENT Hospital of Fudan University (CN)
- Prince of Wales Hospital (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14593
- Citations
- 3
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Key Research and Development Program of Ningxia