Associations of hippocampal volumes, brain hypometabolism, and plasma NfL with amyloid, tau, and cognitive decline
Hippocampal atrophy emerges early with a high amyloid beta burden and exacerbates during the tau-positive phase. Brain hypometabolism and elevated plasma neurofilament light chain (NfL) levels appear mainly in tau-positive stages. Hippocampal volume and plasma NfL levels correlate with cognitive decline in the early to middle stages, while 18F-fluorodeoxyglucose positron emission tomography standardized uptake value ratios in the middle to late stages. Hippocampal atrophy and inferior parietal hypometabolism raise the risk of cognitive impairment in amyloid/tau-positive individuals while adding NfL+ shows no additional effect.
Authors
- Fengfeng Pan
- Fang Xie (ORCID: https://orcid.org/0000-0003-2667-281X)
- Yihui Guan (ORCID: https://orcid.org/0000-0003-3001-7965)
- Chu‐Chung Huang (ORCID: https://orcid.org/0000-0002-9096-9610)
- Yao Lu (ORCID: https://orcid.org/0000-0002-5345-5231)
- Liang Cui (ORCID: https://orcid.org/0000-0003-1112-6162)
- Qi Huang (ORCID: https://orcid.org/0000-0002-9425-6618)
- Qihao Guo (ORCID: https://orcid.org/0000-0001-5079-8047)
- Lin Huang (ORCID: https://orcid.org/0000-0001-7081-8850)
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Sixth People's Hospital (CN)
- Huashan Hospital (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.70005
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- National Natural Science Foundation of China
- Innovation and Technology Commission