Examining multimorbidity contributors to dementia over time
Most dementia cases (71.8%) were attributable to eight chronic conditions. Hypertension was the largest contributor to dementia risk. Confidence intervals were smallest for constituents of a cardiovascular path to dementia. Longitudinal extension of the average attributable fractions (LE-AAFs) explicitly consider longitudinal patterns of comorbidities. Acute myocardial infarction did not contribute significantly to dementia incidence.
Authors
- Heather Allore (ORCID: https://orcid.org/0000-0001-7685-8175)
- Miriam Elman (ORCID: https://orcid.org/0000-0003-3162-6500)
- Matthias Klee (ORCID: https://orcid.org/0000-0002-1629-482X)
- Anja Leist (ORCID: https://orcid.org/0000-0002-5074-5209)
- Ana Quiñones (ORCID: https://orcid.org/0000-0001-6554-7734)
- Sheila Markwardt (ORCID: https://orcid.org/0000-0002-4929-4359)
- Ling Han (ORCID: https://orcid.org/0000-0001-6101-7584)
Institutions
- Oregon Health & Science University (US)
- University of Luxembourg (LU)
- Yale University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14589
- Citations
- 7
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- Yale University
- European Commission
- National Institutes of Health