Metabolic portrait of the indigenous inhabitants of Western Siberia, living on the territory of Khanty-Mansiysk Autonomous Okrug–Yugra

Objective. To analyze the frequency of metabolic syndrome (MS) in indigenous peoples (khanty) living in the Khanty-Mansiysk Autonomous Okrug – Yugra (KhMAO–Yugra). Materials and Methods. In the case-control study included indigenous people (khanty) aged 18 to 44 years living in the territory of the KhMAO–Yugra. Clinical groups are represented by indigenous men and women (khanty) with MS living in the village. All participants underwent anthropometric and laboratory examination. Results. The frequency of MS in indigenous people was 38.2%. Among women MS occurred in 45.1%, which is 25.4% more often than among men (p < 0.001). A statistically significant difference in the frequency of hyperglycemia (p=0.004) and hypercholesterolemia was found in women. 38.5% of khanty people of both sexes with MS had a combination of abdominal obesity with hypertriglyceridemia, low-density lipoprotein hypercholesterolemia, while in men with MS this combination was 22.9% more common than in women with MS. Conclusion. A high prevalence of MS was observed among indigenous young residents living in the KhMAO–Yugra, mainly in women. The combination of abdominal obesity and dyslipidemia is characteristic of indigenous people. In khanty women, the most common lipid metabolism disorders are high-density lipoprotein hypercholesterolemia and hypertriglyceridemia. Men are characterized by the development of low-density lipoprotein hypercholesterolemia.