In-Vitro And In-Vivo Evaluation Of Bilayer Matrix Tablets For Enhanced Gastric Retention And Targeted Drug Delivery

The creation of bilayer matrix tablets for improved stomach retention and tailored drug delivery marks a significant achievement in oral drug delivery systems.This study focusses on the development and testing of bilayer matrix tablets, which have a floating mechanism to enable prolonged stomach residence duration and a tailored release profile for increased therapeutic efficacy.The bilayer design consists of an immediate-release layer for rapid medication onset and a sustained-release layer for long-term drug administration.Key polymers, such as hydroxypropyl methylcellulose (HPMC) and sodium alginate, were used to control drug release rates and tablet floating behaviour.In-vitro studies were conducted to evaluate the drug release kinetics, buoyancy, and matrix integrity under simulated gastric conditions.The results demonstrated that the tablets maintained floatation for over 12 hours and exhibited a controlled release profile consistent with zero-order kinetics, thereby ensuring sustained drug availability in the gastric environment.Furthermore, in-vivo evaluation using animal models confirmed the enhanced gastric retention and targeted drug delivery capabilities of the formulation, as evidenced by prolonged plasma drug levels and improved bioavailability.This study highlights the potential of bilayer matrix tablets as an innovative approach for diseases requiring localized drug action in the stomach or upper gastrointestinal tract, such as gastric ulcers and H. pylori infections.The successful integration of floating mechanisms with targeted drug release offers a promising solution for overcoming the limitations of conventional oral dosage forms, paving the way for improved patient outcomes and therapeutic effectiveness.