Vanillic acid inhibits TGF-β type I receptor to protect bone marrow mesenchymal stem cells from radiation-induced bystander effects
Our findings reveal that radiation causes CTSB overexpression in A549 cells, which further promotes TGF-β1 expression. TGF-β1 activates its receptors on BMSCs to increase ROS levels in BMSCs, while reducing lysosomal double-chain CTSB (dc-CTSB), which results in decreased BMSCs autophagy and an inability to clear ROS, and thus inhibits proliferation. VA inhibits TGFβRI to restore the proliferation of BMSCs, and <i>in vivo</i>, VA can enhance the killing effect of radiation on tumors.
Authors
- Yiming Zhang (ORCID: https://orcid.org/0000-0002-0860-1607)
- Fu-Xian Liu
- Yan Chen (ORCID: https://orcid.org/0000-0001-9311-6077)
- Fan Niu
- Zhiming Miao
- Gu-Cheng Zhou
- Shang-Zu Zhang
- Zhiwei Liu (ORCID: https://orcid.org/0000-0003-4102-9080)
- Jing Li (ORCID: https://orcid.org/0000-0001-8466-8726)
- Yangyang Li (ORCID: https://orcid.org/0000-0002-5751-6468)
- Liying Zhang (ORCID: https://orcid.org/0000-0003-4517-0751)
- Yongqi Liu (ORCID: https://orcid.org/0000-0001-8327-432X)
- Ting Zhou (ORCID: https://orcid.org/0000-0002-8663-2265)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Gansu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/tcr-24-1080
- Citations
- 1
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 1.39