Artificial plasticenta: how polystyrene nanoplastics affect in-vitro cultured human trophoblast cells

Based on electron microscopy and immunofluorescence analysis and <i>in vitro</i> study, we demonstrate the cytotoxicity of PS-NPs in trophoblast cells together with ultrastructural alterations associated with cellular regression and degeneration typical of metabolic stress. An abnormal amount of NPs in the cells might determine a persistent cellular alarm CDR (cell danger response), the evolutionarily conserved metabolic response that protects the cells and hosts from harm triggered by chemical (as in the case of NPs/MPs), physical, or biological agents that exceed the cellular capacity for homeostasis. This <i>in vitro</i> study could further help to demonstrate that the inevitable exposure of MPs/NPs in the environment, which characterizes the modern world, might be partially responsible for the epidemic of non-transmissible disease.

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Publication Details

Journal
Frontiers in Cell and Developmental Biology
Published
2025-02-24
DOI
https://doi.org/10.3389/fcell.2025.1539600
Citations
13
Primary Topic
Microplastics and Plastic Pollution
Type
article
Field-Weighted Citation Impact
6.55
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article

Artificial plasticenta: how polystyrene nanoplastics affect in-vitro cultured human trophoblast cells

Alessandro Svelato, Stefania Annarita Nottola, Loredana Cristiano, Fabio Facchinetti et al.
13 citations
Frontiers in Cell and Developmental Biology
Microplastics and Plastic Pollution
6.55
article

Artificial plasticenta: how polystyrene nanoplastics affect in-vitro cultured human trophoblast cells

Alessandro Svelato, Stefania Annarita Nottola, Loredana Cristiano, Fabio Facchinetti, Giuseppe Familiari, Pierluigi Di Vinci, Caterina De Luca, Antonio Ragusa, Guido Macchiarelli, Denise Rinaldo, Isabella Neri
article en
13 citations

Abstract

Based on electron microscopy and immunofluorescence analysis and <i>in vitro</i> study, we demonstrate the cytotoxicity of PS-NPs in trophoblast cells together with ultrastructural alterations associated with cellular regression and degeneration typical of metabolic stress. An abnormal amount of NPs in the cells might determine a persistent cellular alarm CDR (cell danger response), the evolutionarily conserved metabolic response that protects the cells and hosts from harm triggered by chemical (as in the case of NPs/MPs), physical, or biological agents that exceed the cellular capacity for homeostasis. This <i>in vitro</i> study could further help to demonstrate that the inevitable exposure of MPs/NPs in the environment, which characterizes the modern world, might be partially responsible for the epidemic of non-transmissible disease.

Frontiers in Cell and Developmental BiologyVol. 13
University of Modena and Reggio Emilia (IT), University of L'Aquila (IT), Magna Graecia University (IT), Azienda Ospedaliera Bolognini Seriate (IT), Ospedale Maggiore Carlo Alberto Pizzardi (IT), Azienda Socio Sanitaria Territoriale Bergamo Est, Sapienza University of Rome (IT)
Openalex Percentile: Top 3%
Microplastics and Plastic Pollution
6.55
DOIOpen Access PDFOpenAlex
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