Bioinformatics analysis reveals novel tumor antigens and immune subtypes of skin cutaneous melanoma contributing to mRNA vaccine development
Our findings suggest that the identified tumor antigens could serve as valuable targets for developing mRNA vaccines against SKCM, particularly for patients in immune subtype 1. This research provides valuable insights into personalized immunotherapy approaches for this challenging cancer and highlights the advantages of bioinformatics in identifying immune targets and optimizing treatment approaches.
Authors
- Jie Huang (ORCID: https://orcid.org/0000-0002-0348-6590)
- Ronghua Yang (ORCID: https://orcid.org/0000-0002-9685-7003)
- Deni Kang
- Chen Yao (ORCID: https://orcid.org/0000-0002-3944-7788)
- Jiehua Li (ORCID: https://orcid.org/0000-0001-5903-1563)
- Xinyi Wang (ORCID: https://orcid.org/0009-0002-6349-8013)
- Sitong Zhou (ORCID: https://orcid.org/0000-0003-2082-742X)
- Jia He (ORCID: https://orcid.org/0000-0001-6153-9550)
Institutions
- First People's Hospital of Foshan (CN)
- Guangzhou First People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1520505
- Citations
- 3
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 2.39