Changes in the blood cyclosporine level after switching from voriconazole to isavuconazole in a patient with aplastic anemia: insights from physiologically based pharmacokinetic model simulation and the Adverse Event Reporting System database study
The interaction of isavuconazole with cyclosporine was weaker than that with voriconazole. Maintaining a two-hour dosing interval between isavuconazole and cyclosporine may minimize gastrointestinal drug interactions.
Authors
- Takuya Iwamoto (ORCID: https://orcid.org/0000-0002-6445-4410)
- Hideo Kato (ORCID: https://orcid.org/0000-0002-5272-9560)
- Kazuko Ino (ORCID: https://orcid.org/0000-0003-2063-2614)
- Chihiro Shiraishi (ORCID: https://orcid.org/0000-0002-1190-6540)
Institutions
- Mie University (JP)
- Mie University Hospital (JP)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-02-24
- DOI
- https://doi.org/10.3389/fmicb.2025.1525991
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 2.79