Bone morphogenetic protein 10 is increased in pre-capillary pulmonary hypertension patients
RA BMP10 expression and plasma levels are increased in precPH, likely triggered by excessive RA dilatation and pressure overload. Future studies are needed to determine whether increased BMP10 release is an adaptive mechanism or a potential therapeutic target.
Authors
- Samara M.A. Jansen (ORCID: https://orcid.org/0000-0003-3493-3573)
- Jessie van Wezenbeek (ORCID: https://orcid.org/0000-0002-1091-5445)
- Marie‐José Goumans (ORCID: https://orcid.org/0000-0001-9344-6746)
- Joanne A. Groeneveldt
- Jeroen N. Wessels (ORCID: https://orcid.org/0000-0003-2401-7707)
- M. Louis Handoko (ORCID: https://orcid.org/0000-0002-8942-7865)
- Azar Kianzad (ORCID: https://orcid.org/0000-0003-1238-4139)
- Gonzalo Sánchez‐Duffhues (ORCID: https://orcid.org/0000-0002-3205-0710)
- Clarissa Becher (ORCID: https://orcid.org/0000-0002-1811-8037)
- J. Tim Marcus (ORCID: https://orcid.org/0000-0001-9948-6407)
- Aida Llucià‐Valldeperas (ORCID: https://orcid.org/0000-0002-9723-8343)
- Harm Jan Bogaard (ORCID: https://orcid.org/0000-0001-5371-0346)
- Rowan Smal
- Petr Symersky (ORCID: https://orcid.org/0000-0002-5181-881X)
- Hans W.M. Niessen (ORCID: https://orcid.org/0000-0001-9404-9822)
- Lilian J. Meijboom (ORCID: https://orcid.org/0000-0002-7528-8307)
- Frances S. de Man (ORCID: https://orcid.org/0000-0002-5776-7793)
- Anton Vonk-Noordegraaf
Institutions
- Leiden University (NL)
- Leiden University Medical Center (NL)
- Pulmonary Hypertension Association (US)
- Nanomaterials and Nanotechnology Research Center (ES)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-02-24
- DOI
- https://doi.org/10.1093/cvr/cvaf028
- Citations
- 5
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Fundació la Marató de TV3
- Dutch Cardiovascular Alliance
- Amsterdam University Medical Centers
- Universiteit Leiden
- Hartstichting
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Ministerio de Ciencia e Innovación
- Leids Universitair Medisch Centrum
- Vlaamse regering