Intestinal current measurement detects age-dependent differences in CFTR function in rectal epithelium
These results demonstrate that CFTR function in the rectal epithelium is reduced with increasing age and indicate that this change is likely due to a decline in the number of secretory colonocytes at the crypt base. These findings suggest that differences in CFTR expressing cells may explain increased functional responses to CFTR modulator therapies in children compared to adult people with CF.
Authors
- Stephanie Hirtz
- J. D. Berger
- Olaf Sommerburg (ORCID: https://orcid.org/0000-0002-3941-8944)
- Marcus Alexander Mall (ORCID: https://orcid.org/0000-0002-4057-2199)
- Simon Y. Graeber (ORCID: https://orcid.org/0000-0002-1666-8924)
- Julian Berges
- Heike Scheuermann
- Julia Duerr (ORCID: https://orcid.org/0000-0002-4862-9487)
- Yin Yu
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Humboldt-Universität zu Berlin (DE)
- German Center for Lung Research (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-24
- DOI
- https://doi.org/10.3389/fphar.2025.1537095
- Citations
- 3
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung